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HHS responds to report about autism and acetaminophen

Why it matters

A sitting HHS secretary publicly tying maternal acetaminophen use to autism, and floating leucovorin as a treatment, is a first, and it drew immediate pushback from mainstream researchers. The disagreement itself is the story.

Robert F. Kennedy Jr.

HHS Secretary Robert F. Kennedy Jr. plans to announce that maternal use of acetaminophen (Tylenol) is potentially linked to autism in a new report, according to sources reported by the Wall Street Journal.

The report also will suggest that leucovorin, also known as folinic acid, a medication used in conjunction with cancer drugs like methotrexate to counteract their toxic effects, can be used to treat autism symptoms, the sources said.

“The results of the leucovorin studies so far are inconsistent and based on small studies,” Alycia Halladay, PhD, chief science officer of the Autism Science Foundation, told MedPage Today. “Autism is too complex to be caused by one environmental factor or effectively treated by a single compound.”

In a statement, the Society for Maternal-Fetal Medicine (SMFM) said it continues to advise that acetaminophen is appropriate to treat pain and fever during pregnancy, as untreated fever and pain carry their own risks for the fetus and mother.

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